6 Φεβρουαρίου 2019 - Physiology in Perspective: Responding to a Changing Environment
PHYSIOLOGY 34: 84–85, 2019
Published on line 6 February 2019
Published in print 1 March 2019
The autonomic nervous system regulates a vast landscape of organ and tissue function using multi-level reflex control that involves both central and peripheral neural networks. Modern neuro-electroceutical devices use electrodes with small surface areas to target autonomic nerves for medical therapies. In their review, Horn and colleagues discuss how these devices use novel materials, electrode configurations, stimulation patterns, and closed-loop control to treat heart failure, hypertension, gastrointestinal and bladder diseases, obesity/diabetes, and inflammatory disorders. Critical to progress is a mechanistic understanding of multi-level controls of target organs, disease adaptation, and impact of neuromodulation to restore organ function.
This research has the potential to effectively treat diseases and reduce or eliminate side effects that are common to pharmaceutical approaches.
Full article
Published on line 6 February 2019
Published in print 1 March 2019
The autonomic nervous system regulates a vast landscape of organ and tissue function using multi-level reflex control that involves both central and peripheral neural networks. Modern neuro-electroceutical devices use electrodes with small surface areas to target autonomic nerves for medical therapies. In their review, Horn and colleagues discuss how these devices use novel materials, electrode configurations, stimulation patterns, and closed-loop control to treat heart failure, hypertension, gastrointestinal and bladder diseases, obesity/diabetes, and inflammatory disorders. Critical to progress is a mechanistic understanding of multi-level controls of target organs, disease adaptation, and impact of neuromodulation to restore organ function.
This research has the potential to effectively treat diseases and reduce or eliminate side effects that are common to pharmaceutical approaches.
Full article