A Randomized Trial of Physical Activity in Children and Adolescents with Cancer - Cancers 

Published: 2 January 2021

Malignant diseases and anticancer treatments alter physical activity and performance in children and adolescents. Physical inactivity may cause both early and long-term complications, increasing the disease-associated burden. However, data on the safety and efficacy of physical activity programs in children with cancer are still scarce. In this randomized controlled open-label clinical trial that included 80 children and adolescents with cancer, the six-minute walk test distance (evaluating exercise capacity) was improved in the intervention group (physical activity program) vs. the control group (86 ± 12 m vs. 32 ± 6 m), a significant difference. Several other physical parameters (flexibility, balance, upper and lower limb strength, trunk and abdominal muscle endurance), global self-esteem and parent-reported quality of life were also better in the intervention group. In children and adolescents undergoing treatment for cancer, a physical activity program is safe, improves exercise capacity, and may have persistent physical and psychological benefits.

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