Physical activity (PA) is linked to reduced risk of depression, but research on the objectively measured PA in clinically diagnosed adult outpatients with major depressive disorder (MDD) is scarce. This study aimed to examine relationships of objectively measured PA with depression and mood. A total of 19 outpatients (6 males) with MDD, a mean age of 47.79±11.67 years and mild-moderate depression participated in the study. To record PA, participants wore a triaxial accelerometer device on the right hip during waking hours for seven consecutive days. Depression and mood were assessed with self-reports immediately after day seven.
Participants wore the accelerometers for a high number of days (M=6.26 ± 1.24 days) and hours per day (13.40 ± 2.61 h), recording light (266.01 ± 100.74 min/day) or moderate (31.19 ± 24.90 min/day) PA, and sedentary time (515.33 ± 155.71 min/day). Stepwise regression analysis yield a significant prediction (p < .05) with only moderate PA contributing to the prediction of depression (Beta = −0.47, p < .05). The model explained 22% of the variance of depression. Our findings provide valuable preliminary evidence regarding the relationship between objectively measured PA and lower depression in clinically diagnosed outpatients with MDD, suggesting moderate PA may help alleviating depressive symptoms.

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